Organ dysfunction | Original definitions | Modified definitions |
---|---|---|
Respiratory | paO2/FiO2 < 300 | Intubation |
Renal | Creatinine increase >0.5Â mg/dL or urine output <0.5Â mL/kg/h for at least 2Â h | Creatinine increase >0.5Â mg/dLa |
Coagulopathy | INR >1.5 or aPTT >60Â s | n/a |
Hematologic | Platelet count <100,000/uL | n/a |
Liver | Total bilirubin >4Â mg/dL | n/a |